CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
نویسندگان
چکیده
منابع مشابه
Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.
CD148 is a receptor-like protein-tyrosine phosphatase known to inhibit transduction of mitogenic signals in non-hematopoietic cells. Similarly, in the hematopoietic lineage, CD148 inhibited signal transduction downstream of T cell receptor. However, it also augmented immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src family kinases (SFK). Accord...
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BACKGROUND Adhesion of leukocytes to the extracellular matrix and to other cells is mediated by members of the integrin family of adhesion molecules. Src family kinases are activated upon integrin-mediated adhesion. In lymphocytes, CD45 is a leukocyte-specific transmembrane protein tyrosine phosphatase that activates Src family kinases associated with B-cell and T-cell antigen receptor signalin...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2009
ISSN: 0105-2896,1600-065X
DOI: 10.1111/j.1600-065x.2008.00752.x